We examined the effects of endocrine disruptors on mouse behaviours. After prenatal exposure to endocrine disruptors such as Bisphenol A (BPA), presentation of social male but not female mouse offspring presented interaction deficit in in a dose-dependent manner. This social interaction deficit persisted into adulthood. Significantly less activation in the amgydala was observed in these male offspring after interaction with strangers. Furthermore, BPA exposed amygdalae have less neurons than those in control littermates, and the neurons have shorter dendrites. EEG recording detected that the spindle EEG power was elevated in the theta rhythm range (3.5-7.5Hz) of the adult male BPA exposed offspring.
Thus, we showed a significant correlation between BPA exposure and male-specific social interaction deficit.