Oral Presentation Annual Meetings of the Endocrine Society of Australia and Society for Reproductive Biology and Australia and New Zealand Bone and Mineral Society 2016

Understanding male infertility (#210)

Mark A Baker 1
  1. University of Newcastle, Newcastle, NSW, Australia

Male infertility is a very common condition, with reports suggesting that one in 15 men of reproductive age are affected. The diagnosis of male-factor infertility is difficult and involves discounting female infertility through hormone measurements, pelvic examination and invasive laparoscopy. A semen profile analysis can suggest male infertility, if sperm counts are <15-20 million/ml, or <50% of sperm possess forward progressive motility (and < 25% rapidly progressive sperm) or <4% good morphology sperm. However, the diagnostic potential for a semen analysis is is has been questioned by many reports (1-5).

We have used non-selected, sperm samples from a population of males attending infertility clinics with suspected infertility (asthenozoospermic, teratozoospermic, asthenotetatozoospermic and normozoospermic idiopathic) and performed a quantitative proteomic analysis. Within this analysis, several antimicrobial pre-cursor proteins were found to be vastly up-regulated within the infertile sperm population. Such proteins are cleaved into peptides, which we have now shown to be toxic toward spermatozoa.  A novel model of male infertility will be presented and a possible approach for better sperm selection for ART presented.

  1. David G, et al.,  Fertil Steril 1979;31:103-16.
  2. Smith KD, et al., Fertil Steril 1977;28:1314-9.
  3. Sobrero AJ, Rehan NE. . Fertil Steril 1975;26:1048-56.
  4. Zukerman Z, et al.,.  Fertil Steril 1977;28:1310-3.
  5. van Zyl JA, et al.,. . Int J Fertil 1975;20:129-32.