Vascular Calcification (VC) has been widely reported over the last few decades and is associated with significant morbidity and mortality among patients with chronic kidney disease (CKD). Importantly, these patients have premature and rapidly progressive calcification when compared to general population. VC is an active and complex process closely regulated by a growing list of inducers and inhibitors. There is a direct link between VC and abnormal mineral metabolism and skeletal mineralization. This presentation will provide an overview of the ‘cross-talk’ between bone and vascular disorders, the scientific advances in the pathophysiology of VC and an update on the assessment of VC and bone imaging in CKD.