Oral Presentation Annual Meetings of the Endocrine Society of Australia and Society for Reproductive Biology and Australia and New Zealand Bone and Mineral Society 2016

Using genomics to elucidate developmental cell lineage decisions (#8)

Nathan Palpant 1
  1. University of Queensland, St. Lucia, QLD, Australia

Chromatin modifications demarcate specific types of DNA including actively transcribed genes, repressed DNA, enhancer elements etc. that demarcate part of the epigenetic state controlling cell lineage decisions and functions. We developed a novel computational algorithm that analyzes chromatin in an unbiased manner across the genome to identify genes controlling cell lineage decisions in cardiovascular development. We used this algorithm to elucidate HOPX as a novel regulator of hemogenic endothelium. This approach has broad applications for understanding the genetic/epigenetic basis of developmental processes and disease etiology.