Wayne Tilley is Director of the Dame Roma Mitchell Cancer Research Laboratories and the Adelaide Prostate Cancer Research Centre at the University of Adelaide. His research program is broadly focussed on hormonal carcinogenesis in breast and prostate cancer, with an emphasis on mechanisms of sex hormone signalling and the emergence of resistance to hormonal therapies used in the treatment of these diseases. His laboratory has highlighted the critical role of the androgen receptor (AR) in driving prostate cancer, including evidence for oncogenic potential of the AR, and pioneered research into understanding the pivotal role of the AR in counteracting the proliferative effects of estrogens in the breast. A large majority of breast cancers display AR immunopositivity and it has become clear that this receptor can exert a tumour suppressive or oncogenic influence depending on context. A major objective of our research is to elucidate the mechanisms that underpin the tumour suppressive or oncogenic activity of AR within breast cancer cells. Another research priority is the development of novel single or combinatorial treatments that better target the AR in prostate cancer that may also be useful in the treatment of certain subtypes of breast cancer and the identification of biomarkers of treatment response.
Abstracts this author is presenting: